Research
Morphogenesis of the eye
A major focus our research program is to elucidate the molecular and cellular control of optic cup morphogenesis, and we have focused significant effort on the choroid (optic) fissure and hyaloid vasculature. Read more..........
A major focus our research program is to elucidate the molecular and cellular control of optic cup morphogenesis, and we have focused significant effort on the choroid (optic) fissure and hyaloid vasculature. Read more..........
Retinal Regeneration
We are interested in the genetic underpinnings of lens formation and how defects in this process result in congenital cataracts. Read more........
We are interested in the genetic underpinnings of lens formation and how defects in this process result in congenital cataracts. Read more........
Retina Development
We are interested in the regulation of proliferation and differentiation in retinal progenitor cells (retinoblasts), within the stem cell containing ciliary marginal zone (CMZ) of the retina, and during retinal regeneration post-injury. Read more.........
We are interested in the regulation of proliferation and differentiation in retinal progenitor cells (retinoblasts), within the stem cell containing ciliary marginal zone (CMZ) of the retina, and during retinal regeneration post-injury. Read more.........
RPE Regeneration
We are interested in the development of the RPE, and particularly pigmentation therein, to develop models of ocular and oculocutaneous albinism through which the molecular and cellular underpinnings of melanogenic and ocular defects can be elucidated. Read more.....
We are interested in the development of the RPE, and particularly pigmentation therein, to develop models of ocular and oculocutaneous albinism through which the molecular and cellular underpinnings of melanogenic and ocular defects can be elucidated. Read more.....
RGC Neuroprotection
We are interested in utilizing zebrafish as a platform through which neuroprotective pathways can be identified, which can then be leveraged to develop new treatment strategies for optic neuropathies like glaucoma. Read more.....
We are interested in utilizing zebrafish as a platform through which neuroprotective pathways can be identified, which can then be leveraged to develop new treatment strategies for optic neuropathies like glaucoma. Read more.....
Eye evolution
To better understand the eye of the Urbilaterian ancestor and how complex eye morphologies can evolve, it is essential to establish a Lophotrochozoan model for the development of a cephalic, complex image-forming eye. We have chosen to build off of the rich history of embryology and neurobiology using Loligo pealeii, and further develop it as a model Lophotrochozoan for studies of eye evolution. Read more.....
To better understand the eye of the Urbilaterian ancestor and how complex eye morphologies can evolve, it is essential to establish a Lophotrochozoan model for the development of a cephalic, complex image-forming eye. We have chosen to build off of the rich history of embryology and neurobiology using Loligo pealeii, and further develop it as a model Lophotrochozoan for studies of eye evolution. Read more.....
