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Our research focuses on vertebrate eye development, disease modeling and regeneration utilizing the zebrafish as a model system. Combining forward genetic screens with reverse genetic and embryological manipulations we hope to understand the molecular, cellular and developmental events that regulate eye formation and visual function, ocular diseases and regenerative responses. Current areas of interest in the lab include studies focusing on the development of the retina, lens and retinal pigmented epithelium (RPE), elucidation of the cellular mechanisms that regulate ocular morphogenesis, the molecular regulation of retina and RPE regeneration and neuroprotection. Our research combines molecular, cellular, genomic, biochemical, transgenic and in vivo imaging techniques to address these questions. It is our hope that these studies will ultimately lead to a better understanding of visual system disorders and the development of new therapeutic interventions.
